Lysophosphatidic acid increases phosphatidic acid formation, phospholipase D activity and degranulation by human neutrophils
โ Scribed by Jen-sie Tou; Jacquelyn S. Gill
- Book ID
- 113527665
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 310 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0898-6568
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Phospholipase D (PLD) is activated in mammalian cells in response to a variety of growth factors and may play a role in cell proliferation. Lysophosphatidic acid (LPA) is a bioactive metabolite potentially generated as a result of PLD activation. Two human prostate cancer cell lines, PC-3 and LNCaP,
## Abstract We have previously isolated a 22 kDa protein from a rat brain which was found to be involved in activating phospholipsae D (PLD), and identified the protein as hippocalcin through sequence analysis. Nevertheless, the function of hippocalcin for PLD activation still remains to be resolve