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Lysine 63 Polyubiquitination of the Nerve Growth Factor Receptor TrkA Directs Internalization and Signaling

✍ Scribed by Thangiah Geetha; Jianxiong Jiang; Marie W. Wooten

Book ID: 116754009
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 618 KB
Volume: 20
Category: Article
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2005.09.014

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## Abstract Previous studies have established that reciprocal interactions between the low‐affinity p75 nerve growth factor (NGF) receptor (p75^NTR^) and the high‐affinity TrkA NGF receptor can dictate the cellular response to NGF. As the most important interaction, TrkA signaling was found to inhi