Progressive motor neuron impairment in a
โ
Mimoun Azzouz; Nathalie Leclerc; Mark Gurney; Jean-Marie Warter; Philippe Poindr
๐
Article
๐
1997
๐
John Wiley and Sons
๐
English
โ 114 KB
๐ 2 views
Mutations of Cu,Zn superoxide dismutase cause an autosomal dominant form of familial amyotrophic lateral sclerosis. An animal model of the disease has been produced by expressing mutant human SOD1 in transgenic mice (G93A). In order to quantify the dysfunction of the motor unit in transgenic mice, e