Lyophilized preliposomal formulation of the non-cross-resistant anthracycline annamycin: effect of surfactant on liposome formation, stability and size

Effect of vesicle size and lipid composi

Effect of vesicle size and lipid composition on the in vivo tumor selectivity and toxicity of the non-cross-resistant anthracycline annamycin incorporated in liposomes

✍ Yiyu Zou; Yi-He Ling; Sara Reddy; Waldemar Priebe; Roman Perez-Soler 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 644 KB

Annamycin (Ann) is a non-cross-resistant lipophilic anthracycline antibiotic optimally suited for liposome delivery. We studied how vesicle size and presence of phospholipids with a high phase transition temperature and monosialoganglioside (GM I) in the liposome bilayers affect the pharmacokinetics