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Lynch Syndrome in Young-Onset Colorectal Cancer: Reassessing the Role of the MSH6 Gene

✍ Scribed by Giráldez, Maria Dolores; Castells, Antoni; Castellví-Bel, Sergi


Book ID
121978933
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
125 KB
Volume
9
Category
Article
ISSN
1542-3565

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## Abstract Approximately 1–2% of colorectal cancers (CRC) arise because of germline mutations in DNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and loss of expression of mismatch repair proteins. Pre‐symptomatic identification of mutat