Lymphotoxin: An anticarcinogenic lymphokine as measured by inhibition of chemical carcinogen or ultraviolet-irradiation-induced transformation of syrian hamster cells
✍ Scribed by Charles H. Evans; Joseph A. Dipaolo
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 480 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Syrian‐hamster‐derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen‐induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinogen treatment varies directly with lymphotoxin concentration. The frequency of transformation does not change following re‐feeding with lymphotoxin‐free medium and incubation for 6 additional days. Furthermore, transformation by ultraviolet is prevented when cells are pulsed with lymphotoxin for as few as 6 hours after irradiation. Thus, lymphotoxin has the potential to irreversibly inhibit the first recognizable morphologic step of carcinogenesis.