✦ LIBER ✦
Lymphocytes that mediate systemic resistance to in vivo growth of a carcinogen-induced syngeneic tumor
✍ Scribed by E. D. Crum
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- French
- Weight
- 728 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Wistar rats immunized with irradiated syngeneic methylcholanthrene‐induced sarcoma, Mc7, are able to suppress a subsequent challenge of this tumor. Cells obtained from thoracic‐duct lymph of these tumor‐immunized animals and infused intravenously into normal syngeneic rats transfer specific tumor resistance to the recipients. These mediators of tumor resistance have the characteristics of T lymphocytes that are in a non‐proliferating state and have an effective life span of at least 2 weeks in normal recipient rats.