Lymphocyte subsets in patients with compositae oleoresin dermatitis and increased UVA sensitivity during treatment with azathioprine

✍ Scribed by O. Baadsgaard; C. Geisler; T. Plesner; K. Thestrup-Pedersen

• Book ID: 104789585
• Publisher: Springer-Verlag
• Year: 1985
• Tongue: English
• Weight: 278 KB
• Volume: 277
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00509085

✦ Synopsis

Four patients with severe contact dermatitis resulting from compositae oleoresin were found to have increased sensitivity to ultraviolet light. All showed a clear reduction of Leu-3a-positive lymphocytes (T helper/inducer cells) and cells expressing the Ia phenotype in their blood. The numbers of T suppressor/cytotoxic (Leu 2a) lymphocytes, monocytes and B lymphocytes were within the normal range. Treatment with azathioprine (150 mg daily) improved the eczema. The number of Leu-3a-positive lymphocytes normalized during therapy, but the number of Ia-positive cells did not.