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Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys

✍ Scribed by S. Sopper; C. Stahl-Hennig; M. Demuth; I. C. D. Johnston; R. Dörries; V. ter Meulen

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
183 KB
Volume
29
Category
Article
ISSN
0196-4763

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✦ Synopsis

Rhesus

macaques are invaluable experimental animals in biomedical research. Using three color flow cytometry, we screened anti-human antibodies for crossreactivity with macaque cells in order to determine the distribution of functionally important lymphocyte subsets in blood, lymph nodes (LN), and spleen. NK-cells are almost completely absent in LN. The percentage of B-cells expressing CD80, CD86, and the level of expression of CD20 is higher in blood than in LN. In contrast, a higher proportion of B-cells in LN stains positive for CD21 and CD35. Whereas the number of CD29hi expressing T-cells is lower, CD69 is expressed on more T-cells in LN than in blood. About one-third of CD8؉ T-cells in blood are CD28-, a subset with a unique pattern of antigen expression which cannot be found in LN. In contrast to humans, a relatively high proportion of T-cells in blood also express the co-stimulatory molecules CD80 and CD86. With increasing age, the proportion of B-cells in blood declines, whereas the percentage of T-cells rises. In addition, the proportion of CD29hi expressing T-cells increases among both the CD4؉ and CD8؉ subsets. Cytometry 29:351-362, 1997.

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