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Lymphocyte signaling: Cbl sets the threshold for autoimmunity

✍ Scribed by Christopher E. Rudd; Helga Schneider

Book ID
114317637
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
88 KB
Volume
10
Category
Article
ISSN
0960-9822

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## Abstract T cell (TC) activation requires the coordinated signaling of the T cell receptor (TCR) and coreceptor molecules, allowing TCs to respond to lower degrees of TCR occupancy. Coreceptor molecules set the threshold for TC activation by controlling different regulatory signaling loops. The C