๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Lymphocyte responses and virus excretion as risk factors for intrauterine infection with cytomegalovirus

โœ Scribed by S. Fernando; J. M. Pearce; Dr. J. C. Booth

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
646 KB
Volume
41
Category
Article
ISSN
0146-6615

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โœฆ Synopsis

Abstract

Serological screening of pregnant women in this and a previous study identified 28 cases of primary infection with cytomegalovirus, 7 (25%) of whom transmitted the infection to their fetuses. Risk factors for intrauterine infection were 1) age less than 20 years, 2) Caucasian rather than nonCaucasian race, 3) a weak response to cytomegalovirus antigen in the lymphocyte transformation test, and 4) the excretion of cytomegalovirus in the urine. The greatest risk was when a weak lymphoproliferative response was detected in combination with a positive result for virus isolation, in which case the chance of fetal infection was 83%. Despite these associations, there was one important anomalous result of a woman who demonstrated a strong lymphocyte response during pregnancy and a negative result for virus isolation, but who gave birth to an infected baby who developed unilateral hearing loss.

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