Lymphocyte receptors, signals and cytokines a Newport Beach
โ Scribed by Gerry G.B. Klaus
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 497 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The role of membrane receptors is regarded as being to transduce the signal represented by ligand binding from the external cell surface across the membrane into the cell. Signals are subsequently conveyed from the cytoplasm to the nucleus through a combination of second-messenger molecules, kinase/
he initial signaling event following the engagement of T and B cell antigen receptors (TCR and BCR, respectively) is the activation of Src family protein tyrosine kinases (PTKs) such as Lck and Fyn in T cells and Lyn in B cells (reviewed in Refs. 1, 2). These PTKs phosphorylate tyrosine-containing i
## Assessing the functionality of T lymphocytes is important in determining progression rate in human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), transplant rejection, and autoimmune disease. Activation of T-cells in response to antigen results in expressi
Recent findings have significantly advanced our understanding of the mechanism by which the potent immunosuppressive drug rapamycin inhibits cytokine-dependent lymphocyte proliferation. The protein targeted by the immunophilin-rapamycin complex is a member of a newly defined family of phosphoinositi