Sera from patients with SLE frequently contain IgM and IgG antibodies with multiple specificities for lymphocyte surface determinants, including autologous antigens. The IgM antibodies are of relatively low binding avidity and exhibit broad reactivity with B and T lymphocytes from most individuals.
Lymphocyte Cytotoxic Antibodies in Systemic Lupus Erythematosus
โ Scribed by MITTAL, KAMAL K.; ROSSEN, ROGER D.; SHARP, JOHN T.; LIDSKY, MARTIN D.; BUTLER, WILLIAM T.
- Book ID
- 109670606
- Publisher
- Nature Publishing Group
- Year
- 1970
- Tongue
- English
- Weight
- 290 KB
- Volume
- 225
- Category
- Article
- ISSN
- 0028-0836
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The contribution of immune regulation to the etiology of systemic lupus erythematosus (SLE) is poorly understood. Using the monoclonal antibodies OKT4 and OKTS, we quantitated, by flow cytometry, T inducer/ helper and T cytotoxicfsuppressor cells in patients with SLE. Serologically active patients,
Objective. To examine the relationships among specific lymphocyte antigenic reactivities of lupus sera and central nervous system complications of systemic lupus erythematosus (SLE), lymphocytotoxic antibody (LCA) positivity, and specific cognitive impairment. Methods. Sera from 115 patients with S