Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant

✍ Scribed by Yamamoto, Masuji; Nakagawa, Makiko; Ichimura, Noriko; Ohtsuki, Fumiko; Ohtsuka, Yoshitoshi; Tsujino, Yoshiaki; Tanaka, Aiichiro; Kamiya, Takashi; Wada, Hiroyoshi

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 259 KB
• Volume: 52
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/(sici)1096-8652(199607)52:3<212::aid-ajh14>3.0.co;2-h

✦ Synopsis

A 10-month-old infant with chronic myelomonocytic leukemia (CMML) of 5 months' duration, who had been treated only with transfusion, displayed leukemic transformation characterized by lymphoid morphology, PAS positivity, and myeloperoxidase negativity. Surface marker analysis of blast cells revealed expression of lymphoid-associated antigens (CDlO and CD19) but not myeloid-associated antigens (CD13, CD14, and CD33). These findings suggest that some cases of infantile CMML are clonal disorders arising in a pluripotent stem cell that can also differentiate along the lymphoid cell lineage.