Lymphatic Structure and Function in Health and Disease

✍ Scribed by Felicity N. E. Gavins (editor), J. Steve Alexander (editor)

• Publisher: Academic Pr
• Year: 2019
• Tongue: English
• Leaves: 170
• Edition: 1
• Category: Library

✦ Synopsis

Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction.

• Brings together lymphatic medicine as a whole, with an in-depth analysis of the specific basic science aspects of lymphatic structure and function
• Covers the clinical aspects of lymphatics in different vascular pathologies
• Co-published with the International Society of Neurovascular Diseases
• Discusses lymphatic structure and function in all of the major organ systems

✦ Table of Contents

Cover
LYMPHATIC STRUCTURE
AND FUNCTION IN HEALTH
AND DISEASE
Copyright
Dedication
Contributors
About the Editors
1
Introduction/overview
2
Ontogeny and phylogeny of lymphatics: Embryological aspect
Historical background
Ontogenic point of view
Phylogenetic point of view
Vasculogenetic point of view
Conclusion
References
Further reading
3
Lymphatic pumping and pathological consequences of its dysfunction
The lymphatic system
Origin and mechanisms of lymphatic pumping
Electrical activity and pacemaker of the lymphatic muscle
Mechanisms of lymphatic contraction
Regulation of lymphatic pumping
Mechanical regulation
Chemical regulation
Lymphatic alterations during disease
Lymphadenopathy
Lymphangiogenesis
Lymphangiectasia
Lymphatic pumping in diseases
Primary lymphedema
Secondary lymphedema
Changes during chronic inflammation
Arthritic diseases
Inflammatory bowel disease
Metabolic syndrome and diabetes
Cancer
Targeting the lymphatic pump for therapeutic benefits
Conclusions
References
4
Hydrodynamic regulation of lymphatic vessel transport function and the impact of aging
Concepts of intrinsic and extrinsic lymph pumps
Intrinsic lymph pump
Extrinsic lymph pump
Modulation of the lymphatic vessel contractility by pressure/stretch
Modulation of the lymphatic vessel contractility by intrinsic and extrinsic flows
Histamine as endothelium-derived relaxing factor in mesenteric lymphatic vessels
Influences of aging
References
5
CNS lymphatics in health and disease
Lymphatics of the central nervous system
The perivascular pathway
The glymphatic pathway
The meningeal pathway
The role of the lymphatic system in diseases of the CNS
Alzheimer's disease
Multiple sclerosis
Cerebral ischemic injury and microinfarcts
Aging
Exploiting the CNS lymphatics for drug discovery
Maximizing drug delivery into the lymphatics
Summary
Acknowledgments
References
6
Defective development of the peripheral lymphatic system: Lymphatic malformations
General aspects
Embryological aspects
Clinical aspects
Genetic considerations (see Table 1)
Management
References
7
Cardiac lymphatics and cardiac lymph flow in health and disease
Cardiac lymphatics
Flow of lymph in the heart
Lymphatics within different cardiac structures
Cardiac inflammation and lymphatics
Valves in lymphatic vessels
Cardiac conditions that may be exacerbated by lymphatic obstruction, lymphangitis, or obliteration
Effects of experimental ablation of cardiac lymphatics
Experimental manipulation of lymphatics as a form of cardiac therapy
Summary
References
Further reading
8
Lymphatic reconstruction
Introduction
History of surgical approaches for lymphatic reconstruction
Current options for lymphatic reconstruction
Lymphaticovenular anastomosis
Vascularized lymph node transfer
Lympholymphatic graft
Conclusion
References
Index
A
C
D
E
F
G
H
I
K
L
M
N
O
P
R
S
T
V
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