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Lymph node metastasis in lower lip squamous cell carcinoma in relation to tumour size, histologic variables and p27Kip1 protein expression

✍ Scribed by Vito Rodolico; Elisa Barresi; Roberto Di Lorenzo; Vincenza Leonardi; Pietro Napoli; Francesca Rappa; Cristofaro Di Bernardo

Book ID: 114394054
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 184 KB
Volume: 40
Category: Article
ISSN: 1368-8375
DOI: 10.1016/s1368-8375(03)00141-6

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio