Lymph node and perinodal tissue tumor involvement in patients with esophagectomy and three-field lymphadenectomy for carcinoma of the esophagus
✍ Scribed by Baba, Masamichi; Aikou, Takashi; Natsugoe, Shoji; Kusano, Chikara; Shimada, Mario; Kimura, Shigeto; Fukumoto, Toshitaka
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 274 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-4790
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✦ Synopsis
Background:
Lymph node metastasis is a definitive prognostic factor; however, perinodal fat tumor invasion has not been fully elucidated.
Methods:
Periesophageal nodes and the surrounding fibrofatty tissue obtained from 131 patients who underwent esophagectomy were examined.
Results:
Of 9,789 nodes removed, 645 (6.6%) demonstrated invasion and 143 (1.5%) showed perinodal involvement. of 131 patients 97 (74.0%) had lymph node involvement and 43 (32.8%) had perinodal fat involvement. the incidence of perinodal tissue involvement correlated significantly with the number of nodes involved; 23 (42.6%) of 54 patients with a total of 1-8 nodes involved and 19 (95.0%) of 20 patients with 9 or more involved nodes had perinodal involvement. the 5-year survival for 33 patients without involved nodes or perinodal tissue extension was 59.7%, compared to 14.0% for 43 patients with perinodal fat involvement.
Conclusion:
Perinodal tissue carcinoma into the periesophageal fibrofatty tissue was a decisive prognostic factor in patients with curative resection for esophageal carcinoma.