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LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats

โœ Scribed by J. Konieczny; K. Ossowska; S. Wolfarth; A. Pilc


Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
75 KB
Volume
358
Category
Article
ISSN
0028-1298

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Efficient synthesis of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740: 1) and its structurally related analogs (-)-2 and (-)-3 has been accomplished starting with (1S,2R)-1-amino-2-hydroxycyclopentane-or cyclohexanecarboxylic acid (4 or 17 ) via an intramolecular cyclopropanation of