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LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

✍ Scribed by A.E Kingston; P.L Ornstein; R.A Wright; B.G Johnson; N.G Mayne; J.P Burnett; R Belagaje; S Wu; D.D Schoepp


Book ID
117188013
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
379 KB
Volume
37
Category
Article
ISSN
0028-3908

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Efficient synthesis of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740: 1) and its structurally related analogs (-)-2 and (-)-3 has been accomplished starting with (1S,2R)-1-amino-2-hydroxycyclopentane-or cyclohexanecarboxylic acid (4 or 17 ) via an intramolecular cyclopropanation of