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LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway

✍ Scribed by Jiang, Chuanlu

Book ID
120191755
Publisher
Spandidos Publications Ltd
Year
2011
Tongue
English
Weight
588 KB
Category
Article
ISSN
1791-2997

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In vitro experiments have shown that the establishment of cell-cell contacts in intestinal epithelial cell cultures is a critical step in initiating ERK inhibition, cell cycle arrest, and induction of the differentiation process. Herein, we determined the mechanisms through which E-cadherin-mediated