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LY294002 and rapamycin co-operate to inhibit T-cell proliferation

โœ Scribed by Elaine M Breslin; Paul C White; Angharad M Shore; Mathew Clement; Paul Brennan


Book ID
110008576
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
443 KB
Volume
144
Category
Article
ISSN
0007-1188

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Longitudinal inhibition of PI3K/Akt/mTOR
โœ Takayuki Ikezoe; Chie Nishioka; Kentaro Bandobashi; Yang Yang; Yoshio Kuwayama; ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 1006 KB

This study found that phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling was activated in human T-cell lymphotropic virus type I (HTLV-1)-infected leukemia cells. Rapamycin (1-100 nM, 48 h), the inhibitor of mTOR and its analog RAD001 (1-100 nM, 48 h)-induced gro