✍ Scribed by Jean-Charles Piette; Eduardo Marinho; Du Le Thi Huong; Zahir Amoura; Camille Francès
No coin nor oath required. For personal study only.
108, i.e., 8 recurrences ϩ 2 concordant twins/57 children born before and 47 after the index delivery ϩ 4 twins). Of the 33 pregnancies immediately subsequent to the index delivery, 6 (18%) were complicated by CHB.
Although isolated CHB defined using stringent inclusion criteria is practically always immune mediated (3), our results may not be generalizable to all studies in which maternal antibodies to SSA and/or SSB are an inclusion criterion. However, our findings are quite similar to previously reported results. In a review including 5 studies published between 1981 and 1987 and reporting sibling data from 64 index cases, the risk of recurrence was 1 in 3 (4). In a multicenter study by Scott et al, this risk was 20% (4 of 20) (5). Waltuck and Buyon recruited 57 mothers of children with CHB from many different sources, and reported that 4 (15%) of 26 subsequent pregnancies in 23 women were complicated by CHB (6). A recent study reported data from the Research Registry for Neonatal Lupus including 105 affected mothers whose sera contained anti-SSA and/or SSB; 8 (16%) of the 49 pregnancies immediately subsequent to the birth of a child with CHB resulted in a second child with CHB (7).
In this nationwide study, we identified the majority of children with isolated CHB born in Finland between 1950 and 1999 and collected familial data from practically all mothers of these children. We consider that our study had no selection bias, and the number of pregnancies studied was sufficiently large. The 17% rate of recurrence of CHB found in this study may be considered high by affected mothers.
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