Lung carcinoma trends by histologic type in Vaud and Neuchâtel, Switzerland, 1974–1994
✍ Scribed by Fabio Levi; Silvia Franceschi; Carlo La Vecchia; Lalao Randimbison; Van-Cong Te
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 202 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
dence is increasing. The authors evaluated lung carcinoma incidence rates in two Swiss cantons for changes in trends by gender, birth cohort, and histologic type.
1 Registre Vaudois des Tumeurs, Institut uni-
METHODS.
The authors analyzed data on population-based lung carcinoma inciversitaire de me ´decine sociale et pre ´ventive, dence from the Swiss cantons of Vaud and Neucha ˆtel (the populations of which Lausanne, and Registre Neucha ˆtelois des Tumeurs, Les Cadolles, Neucha ˆtel, Switzerland. total about 760,000). Cancers were grouped into four major histologic types. The proportion of cancers not histologically confirmed was approximately 8% across 2 Servizio di Epidemiologia, Centro di Riferithe entire study period. Incidence rates were age-standardized on the basis of the mento Oncologico, Aviano, Italy. world standard population. 3 Istituto di Ricerche Farmacologiche ''Mario RESULTS. Overall, of 7423 cancer cases diagnosed in the period 1974-1994, squa-Negri,'' Milano, Italy; Istituto di Statistica Medmous cell carcinomas accounted for 37%, small cell carcinomas and adenocarcinoica e Biometria, Universita `degli Studi di Milano, mas 18% each, and other carcinomas 16%. Rates of squamous cell and small cell Milano, Italy; and Department of Epidemiology, carcinoma incidence in males of all ages dropped in the last quinquennium, while Harvard School of Public Health, Boston, Mascorresponding rates in females increased steadily. Conversely, adenocarcinoma sachusetts.
incidence increased in both genders by approximately 2.5-fold; and during the period 1990-1994, in young adults of both genders, it was more than 3-fold higher than the incidence of squamous cell carcinoma. At variance with squamous cell carcinoma, the incidence of which reached its peaks in the 1910-20 birth cohorts in males and in the 1930-40 birth cohorts in females, adenocarcinoma revealed a similar birth cohort pattern in the two genders, with still no sign of decline.
CONCLUSIONS.
Although changes in diagnostic practices may have played a role, the incidence data presented in this study suggest that adenocarcinoma is sustaining a new lung carcinoma epidemic, chiefly attributable to the switch to lowtar, filtered cigarettes. Its pattern seems remarkably similar in the two genders.
Thus, the authors conclude that similar exposure to tobacco-related carcinogens leads to similar rates of histologic type-specific lung carcinoma incidence in males and females.