Lung Biology in Health & Disease Volume 175 Oxygen Sensing: Responses and Adaptation to Hypoxia

✍ Scribed by Sukhamay Lahiri, Gregg Semenza, Nanduri R. Prabhakar

Year: 2003
Tongue: English
Leaves: 815
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Reviewing research on the molecular basis of oxygen homeostasis, this text describes the changes in intracellular signalling and gene expression that lead to physiological responses to hypoxia in unicellular, invertebrate, and mammalian species. It examines O2 sensing systems in bacteria and archaea and demonstrates interrelationships among cell proliferation, energy metabolism, oxygen homeostasis, redox states, signal transduction and gene expression in humans and other organisms. The book describes the effect of hypoxia on carotid body structure and function and the effect of alterations in oxygen homeostasis on the pathophysiology of cardiac ischemia, cancer, stroke, and chronic lung disease.

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