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Luminal Cathepsin G and Protease-Activated Receptor 4: A Duet Involved in Alterations of the Colonic Epithelial Barrier in Ulcerative Colitis

✍ Scribed by Marta Dabek; Laurent Ferrier; Richard Roka; Krisztina Gecse; Anita Annahazi; Jacques Moreau; Jean Escourrou; Christel Cartier; Gilles Chaumaz; Mathilde Leveque; Afifa Ait-Belgnaoui; Tibor Wittmann; Vassilia Theodorou; Lionel Bueno


Book ID
117970930
Publisher
American Society for Investigative Pathology
Year
2009
Tongue
English
Weight
536 KB
Volume
175
Category
Article
ISSN
0002-9440

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## Background: Cathepsin g (cat-g) is a neutrophil serine-protease found in the colonic lumen of ulcerative colitis (uc) patients. cat-g is able to activate protease-activated receptor-4 (par(4) ) located at the apical side of enterocytes, leading to epithelial barrier disruption. however, the mech