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Lujan-Fryns syndrome in the differential diagnosis of schizophrenia

✍ Scribed by De Hert, Marc; Steemans, Dirk; Theys, Paul; Fryns, Jean-Pierre; Peuskens, Jozef

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 6 KB
Volume: 67
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19960409)67:2<212::aid-ajmg13>3.0.co;2-m

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✦ Synopsis

Schizophrenia is considered to be a heterogenous disorder. Different etiopathological mechanisms can be attributed to a similar clinical picture as described in DSM-111-R criteria. We present a case of a young man diagnosed on different occasions as schizophrenic with mild mental retardation. Clinical examination revealed signs and symptoms most compatible with the diagnosis of Lujan-Fryns syndrome, an X-linked mental retardation syndrome with marfanoid features, frequently associated with psychotic or other psychiatric symptoms. In all patients with symptoms of schizophrenia and mental retardation Lujan-Fryns syndrome should be considered in the differential diagnosis.

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