Six hundred years after Poggio’s retrieval of the De rerum natura, and with the recent surge of interest in Lucretius and his influence, there has never been a better time to fully assess and recognize the shaping force of his thought and poetry over European culture from antiquity to modern times. This volume offers a multidisciplinary and updated overview of Lucretius as philosopher and as poet, with special attention to how these two aspects interact. The volume includes 18 contributions by established as well as early career scholars working on Lucretius’ philosophical and poetic work, and his reception both in ancient and early modern times. All the chapters present new and original research. Section I explores core issues of Epicurean-Lucretian epistemology and ethics. Section II expounds much new material on ancient response to and reception of Lucretius. Section III presents new material and analysis on the immediate, fraught early modern reception of the poem. Section IV offers a wide collection of new and original papers on Lucretius’ fortunes in the period from Machiavelli up to Victorian times. Section V explores little known aspects of the iconographical and biographical motifs related to the De rerum natura.