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Lubricin surface modification improves tendon gliding after tendon repair in a canine model in vitro

✍ Scribed by Manabu Taguchi; Yu-Long Sun; Chunfeng Zhao; Mark E. Zobitz; Chung-Ja Cha; Gregory D. Jay; Kai-Nan An; Peter C. Amadio

Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
257 KB
Volume
27
Category
Article
ISSN
0736-0266

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✦ Synopsis

Abstract

This study investigated the effects of lubricin on the gliding of repaired flexor digitorum profundus (FDP) tendons in vitro. Canine FDP tendons were completely lacerated, repaired with a modified Pennington technique, and treated with one of the following solutions: saline, carbodiimide derivatized gelatin/hyaluronic acid (cd‐HA‐gelatin), carbodiimide derivatized gelatin to which lubricin was added in a second step (cd‐gelatin + lubricin), or carbodiimide derivatized gelatin/HA + lubricin (cd‐HA‐gelatin + lubricin). After treatment, gliding resistance was measured up to 1,000 cycles of simulated flexion/extension motion. The increase in average and peak gliding resistance in cd‐HA‐gelatin, cd‐gelatin + lubricin, and cd‐HA‐gelatin + lubricin tendons was less than the control tendons after 1,000 cycles (p < 0.05). The increase in average gliding resistance of cd‐HA‐gelatin + lubricin treated tendons was also less than that of the cd‐HA‐gelatin treated tendons (p < 0.05). The surfaces of the repaired tendons and associated pulleys were assessed qualitatively with scanning electron microscopy and appeared smooth after 1,000 cycles of tendon motion for the cd‐HA‐gelatin, cd‐gelatin + lubricin, and cd‐HA‐gelatin + lubricin treated tendons, while that of the saline control appeared roughened. These results suggest that tendon surface modification can improve tendon gliding ability, with a trend suggesting that lubricin fixed on the repaired tendon may provide additional improvement over that provided by HA and gelatin alone. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:257–263, 2009

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