✦ LIBER ✦

LTP and LTD: An Embarrassment of Riches

✍ Scribed by Robert C. Malenka; Mark F. Bear

Book ID: 116782071
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 155 KB
Volume: 44
Category: Article
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2004.09.012

No coin nor oath required. For personal study only.

✦ Synopsis

LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission, are widespread phenomena expressed at possibly every excitatory synapse in the mammalian brain. It is now clear that “LTP” and “LTD” are not unitary phenomena. Their mechanisms vary depending on the synapses and circuits in which they operate. Here we review those forms of LTP and LTD for which mechanisms have been most firmly established. Examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function.

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