LTD, LTP, and the sliding threshold for long-term synaptic plasticity

✍ Scribed by Patric K. Stanton

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 889 KB
• Volume: 6
• Category: Article
• ISSN: 1050-9631
• DOI: 10.1002/(sici)1098-1063(1996)6:1<35::aid-hipo7>3.0.co;2-6

✦ Synopsis

be necessary. Second, an "anti-hebbian" form of LTD, in which presynaptic activity that is unable to cause postsynaptic excitation depresses synaptic strength, could serve to improve the signal-to-noise ratio of sensory input activation of stored memories, by maximizing the ductances also confers on neurons the ability to compute and store a covariance function between converging neuronal inputs. The forms and properties of LTD expressed, physiological patterns of stimulation that induce LTD, and neurochemistry of induction and maintenance are all areas of expanding research.

Long-term potentiation (LTP) is a long-lasting increase in synaptic strength which has attracted a great deal of interest as a possible synaptic mechanism of both learning and memory, and experience-dependent development of cortical circuitry. More recently, long-term depression (LTD) of synaptic efficacy has also been demonstrated in both the hippocampus and a growing list of neocortical areas. In this chapter, I will review the .

LTD is facilitated by the blockade of inhibition (Abraham and Wickens, 1991), that activation of L-type voitage-dePendenr to induce heterosynaptic LTD (Wickens and Abraham,