## Abstract The latent TGF‐β binding proteins (LTBP) ‐1, ‐3, and ‐4 are extracellular proteins that assist in the secretion and localization of latent TGF‐β. The null mutation of LTBP‐4S in mice causes defects in the differentiation of terminal air‐sacs, fragmented elastin, and colon carcinomas. We
LTBP-4 function as a modulator of TGF-β and elastogenesis in lung
✍ Scribed by Branka Dabovic; Yan Chen; Jiwon Choi; Elaine Davis; Harry Dietz; Francesco Ramirez; Harold von Melchner; Daniel Rifkin
- Book ID
- 116729736
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 62 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0945-053X
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## Abstract Transforming growth factor (TGF)‐β is secreted and targeted into the extracellular matrix (ECM) in association with one of the latent TGF‐β binding proteins (LTBPs). Activation of these latent complexes is an important regulatory step in TGF‐β signaling. LTBPs target the growth factor i
## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut