LRRK2 mutations and Parkinsonism
β Scribed by Mathias Toft; Ignacio F Mata; Jennifer M Kachergus; Owen A Ross; Matthew J Farrer
- Book ID
- 117294265
- Publisher
- The Lancet
- Year
- 2005
- Tongue
- English
- Weight
- 79 KB
- Volume
- 365
- Category
- Article
- ISSN
- 0140-6736
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## Abstract Tremor dominant parkinsonism (TDP) is characterized by initial prominent resting and action tremor, mild parkinsonism, unpredictable response to medication, and a better prognosis than idiopathic Parkinson's disease (PD). We report on clinical features and longitudinal course of 26 pati
Stimulation of the subthalamic nucleus (STN) improves motor signs in patients with levodopa-responsive Parkinson's disease (PD). Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause Parkinsonism. We assessed 69 patients under STN stimulation and found heterozygous LRRK2 mutations in 9 (G