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LRRK2 is an Interferon-gamma Target Involved in Immune Responses

✍ Scribed by Agnes Gardet; Yair Benita; Isabel Ballester; Bruce Sands; Joshua Korzenik; Mark Daly; Ramnik Xavier; Daniel Podolsky

Book ID
113541577
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
43 KB
Volume
135
Category
Article
ISSN
1090-2341

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## Abstract We previously identified a 1.2 Kb DNA element (P‐1161/+16), 5β€² to __caspase‐8__ exon‐1, that acts as promoter in caspase‐8‐positive, but not in caspase‐8‐negative neuroblastoma (NB) cells. The P‐1161/+16 DNA element regulates both constitutive and interferon IFN‐γ‐inducible caspase‐8 ex