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LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density

✍ Scribed by Takeshi Mizuguchi; Itsuko Furuta; Yukio Watanabe; Kazuhiro Tsukamoto; Hiroshi Tomita; Mitsuhiro Tsujihata; Tohru Ohta; Tatsuya Kishino; Naomichi Matsumoto; Hisanori Minakami; Norio Niikawa; Koh-ichiro Yoshiura

Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
217 KB
Volume
49
Category
Article
ISSN
1435-232X

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## Abstract The aim of this study was to investigate the activation of the Wnt/β‐catenin pathway in osteoarthritis and the role of low‐density lipoprotein receptor‐related protein 5 (LRP5) in human osteoarthritic chondrocytes. The influence of 1,25(OH)~2~D~3~ on the expression of the __LRP5__ gene

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We identified seven novel polymorphisms in the human low density lipoprotein receptor related protein 5 (LRP5) gene. Two of them are predicted to replace amino acid in LRP5 protein (c.314A>G: Q89R and c.4037T>C: V1330A), whereas three are silent mutations in the coding region (c.2268T>C: N740N, c.34