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LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells

✍ Scribed by Marina G. Smirnova; Li Guo; John P. Birchall; Jeffrey P. Pearson

Book ID
114008242
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
291 KB
Volume
221
Category
Article
ISSN
0008-8749

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The effect of cannabinoids on the induction of cytokine mRNA by rat microglial cells was examined. Exposure of neonatal rat cortical microglial cells to the exogenous cannabinoid ␦ 9 -tetrahydrocannabinol (THC) resulted in reduced amounts of lipopolysaccharide (LPS)-induced mRNAs for IL-1␣, IL-1␀, I