Lowering of tumoral interstitial fluid pressure by prostaglandin E1 is paralleled by an increased uptake of 51Cr-EDTA
✍ Scribed by Kristofer Rubin; Mats Sjöquist; Ann-Marie Gustafsson; Britta Isaksson; Gerd Salvessen; Rolf K. Reed
- Book ID
- 102650018
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 607 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
High intra-tumoral fluid pressure (TP IF ) may impair uptake of anticancer drugs into tumors, contributing to poor efficiency in treatment of carcinomas. Here, we demonstrate that lowering of TP IF parallels increased transport of 51 Cr-EDTA (m.w. 341) into tumor interstitium. Introduction of 15 g prostaglandin E 1 (PGE 1 ) -methyl ester into the s.c. tissue surrounding transplanted rat colonic (PROb) carcinomas or chemically-induced rat mammary carcinomas, lowered TP IF by 30%. Transcapillary transport into the interstitium of PROb tumors quantified by microdialysis increased by 39.6% after PGE 1 treatment 40 min prior to administration of 51 Cr-EDTA (n;6؍ p<0.05) compared to vehicle (n.)01؍ In mammary tumors, PGE 1 increased transport into the tumors by 86.9% over controls (n;61؍ p<0.05). Both tumors had well developed stroma containing collagen and hyaluronan. Our data demonstrate that adjuvant treatment with PGE 1 lowers TP IF , and enhances transport into the tumors. This principle may be of value as adjuvant therapy in treatment of solid malignancies with currently used anticancer drugs. Int.