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Lowering of p27Kip1 levels by its antisense or by development of resistance to 1,25-dihydroxyvitamin D3 reverses the G1 block but not differentiation of HL60 cells

✍ Scribed by Wang, Q M; Chen, F; Luo, X; Moore, D C; Flanagan, M; Studzinski, G P

Book ID
110053910
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
375 KB
Volume
12
Category
Article
ISSN
0887-6924

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✍ Xuening Wang; George P. Studzinski 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 351 KB

## Abstract We are interested in determining the signaling pathways for 1,25‐dihydroxyvitamin D~3~ (1,25D)‐induced differentiation of HL60 leukemic cells. One possible candidate is Raf‐1, which is known to signal cell proliferation and neoplastic transformation through MEK, ERK, and downstream targ