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Lower frequency of apolipoprotein E4 allele in an “elderly” Down's syndrome population

✍ Scribed by Mary Cosgrave; Janette Tyrrell; Hanna Dreja; Ziarih Hawi; Brian A. Lawlor; Michael Gill


Book ID
118858088
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
209 KB
Volume
40
Category
Article
ISSN
0006-3223

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Alzheimer's disease and apolipoprotein e
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## Abstract Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and preseuilin II, cause early‐onset AD. The apolipoprotein E (APOE) gene contributes primarily to late‐onset AD. The APOE‐