Lower airways may also be affected in asymptomatic patients with recent onset of allergic rhinitis
✍ Scribed by Giorgio Ciprandi; Ignazio Cirillo; Catherine Klersy
- Book ID
- 102452163
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 98 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0023-852X
No coin nor oath required. For personal study only.
✦ Synopsis
Objectives/hypothesis:
It is well known that there is a close association between allergic rhinitis (ar) and asthma, and ar is a strong risk factor for the onset of asthma. ar duration is significantly associated with a possible bronchial involvement. the aim of this study was to investigate the presence of possible spirometric abnormalities and bronchial hyperreactivity (bhr) in a large group of patients with recent onset of ar.
Study design:
Observational cross-sectional study.
Methods:
A total of 1,539 ar patients were consecutively evaluated. clinical examination, skin prick test, spirometry, and methacholine challenge were performed on all patients.
Results:
: there were 362 (23%) patients with fef(25-75) values <70% of predicted. the methacholine challenge was positive in 74.43% of patients, and 72.22% of the population presented a polysensitization. at multivariable analysis, an fev(1) value lower than 92% of predicted, as well as increasing severity of bhr and polysensitization appeared to be independent predictors of a reduced fef(25-75) value.
Conclusions:
This study shows that reduced fef(25-75) values may be present in some patients with recent onset of ar. fev(1) <92%, severity of bhr, and polysensitization may be considered risk factor for this phenomenon.