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Low sweat electrolytes in a patient with cystic fibrosis

✍ Scribed by Pamela B. Davis; Van S. Hubbard; Paul A. Di Sant'Agnese

Book ID
115678368
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
463 KB
Volume
69
Category
Article
ISSN
1555-7162

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pH of the sweat from patients with cystic fibrosis and in controls was measured as a function of the sweat-rate using a fluorescence-pH-indicator (umbelliferone). In both populations sweat is acid at low sweat-rates and alkaline at high ones. The results do not favour an abnormality of the ductal H+

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A total of 540 individuals with clinical signs suggestive of cystic fibrosis (CF) was studied. The sweat chloride was measured and the DF508, G542X, R553X, and W1282X mutations of the CF gene were screened by polymerase chain reaction (PCR). With this approach the diagnosis of CF was confirmed in 12