Low Sequence Variation in the Gene Encoding the Human β-Myosin Heavy Chain
✍ Scribed by Kalev Freeman; Koichi Nakao; Leslie A Leinwand
- Book ID
- 115615468
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 155 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0888-7543
No coin nor oath required. For personal study only.
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The entire gene coding for the human beta-myosin heavy chain has been isolated from genomic EMBL3A phage libraries by chromosomal walking starting from clone gMHC-1, reported earlier (Appelhans and Vosberg 1983). gMHC-1 has been shown to carry coding information for the C-terminal two-thirds of beta
During the initial stages of B lymphocyte differentiation heavy chain variable (VH), diversity (DH) and joining (JH) gene segments recombine to form a functional heavy chain variable region (VDJ) gene. Evidence for genetic polymorphism of the human JH gene segments has been obtained from mature rear