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Low sensitivity of the comet assay to detect acetaldehyde-induced genotoxicity

✍ Scribed by Günter Speit; Manuela Fröhler-Keller; Petra Schütz; Simone Neuss

Book ID
116759493
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
325 KB
Volume
657
Category
Article
ISSN
1383-5718

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The alkaline comet assay is a sensitive test for the detection of a variety of DNA lesions. However, crosslinks are not readily detected under standard test conditions. Recently, modifications have been introduced measuring crosslinks by determining the reduction of induced DNA migration. We used th