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Low plasma androgens in women with active or quiescent systemic lupus erythematosus

✍ Scribed by Paul Jungers; Khalil Nahoul; Clara Pelissier; Maxime Dougados; FrançLois Tron; Jean-FrançOis Bach

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
347 KB
Volume
25
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

✦ Synopsis

Because women comprise the majority of patients with systemic lupus erythematosus (SLE) (1) and androgens confer protective effects in murine lupus (2-5), it seems possible that sex-linked hormonal factors may modulate the expression of the disease. Serum testosterone levels have already been studied in men who have SLE (6,7), but data on androgen metabolism in women who have SLE are still lacking. We assessed plasma androgen levels in female SLE patients. Preliminary results in the quiescent phase of the disease showed low plasma androgen levels (8); now we have completed our tests and also studied patients during the active phase of their disease.

PATIENTS AND METHODS

Patients. Thirteen female SLE patients between 18 and 42 years of age were studied. All had regular menses, none of them had received oral contraceptive therapy, nor had any been previously treated with cyclophosphamide; liver enzymes were normal in all at the time of study.

The patients were divided into two groups (Table I), according to the disease activity defined on a clinical basis

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