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Low-pH-Sensitive PEG-Stabilized Plasmid−Lipid Nanoparticles: Preparation and Characterization

✍ Scribed by Choi, Joon Sig; MacKay, J. Andrew; Szoka, Francis C.

Book ID
120546895
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
619 KB
Volume
14
Category
Article
ISSN
1043-1802

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Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery
✍ Weijun Li; Zhaohua Huang; J. Andrew MacKay; Stefan Grube; Francis C. Szoka Jr. 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 483 KB

## Abstract ## Background We have studied the effects of the poly(ethylene glycol) (PEG) chain length and acyl chain composition on the pH‐sensitivity of acid‐labile PEG‐diorthoester (POD) lipids. The optimal conditions are described for preparation of DNA plasmid encapsulated POD nanolipoparticle