Low-osmolality contrast media: Dosage comparison of ioversol and iohexol for cranial computed tomography

✍ Scribed by Matthew J. Kuhn; Scott D. Long; Marc A. DeSio

• Book ID: 103927590
• Publisher: Elsevier Science
• Year: 1991
• Tongue: English
• Weight: 390 KB
• Volume: 15
• Category: Article
• ISSN: 0895-6111
• DOI: 10.1016/0895-6111(91)90166-s

✦ Synopsis

One hundred patients undergoing cranial computed tomography were evaluated in this prospective, randomized, double-blind comparative study. Patients received 50 mL of ioversol 320 (16 g iodine), 75 mL of ioversol 320 (24 g iodine), 100 mL of iohexol 240 (24 g iodine), 100 mL of iohexol 300 (30 g iodine) or 150 mL of iohexol 240 (36 g iodine). Twenty patients were enrolled in each treatment group. No patient in any treatment group experienced any contrast-media-related adverse reaction. Results of this study coupled with our prior work suggests that the lowest dose and optimal concentration of low-osmolality contrast media necessary to produce diagnostic cranial computed tomography is 32 g of iodine administered in a concentration of 320 mg/100 mL iodine.