Low-molecular-weight heparin-induced skin necrosis
✍ Scribed by W. Füreder; P. A. Kyrle; H. Gisslinger; K. Lechner
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 205 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0939-5555
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Two patients developed catastrophic multicentric skin necrosis while receiving warfarin to treat venous thromboembolism complicated by immune-mediated heparin-induced thrombocytopenia (HIT). Patient 1 developed skin necrosis involving the breasts, thighs, and face, as well as venous limb gangrene an
The main objective of this study was to determine if the systemic absorption of therapeutic amounts of heparin was possible following nasal administration. Sprague-Dawley rats received nosedrops containing a low molecular weight heparin (LMWH) or unfractionated heparin (UFH) formulated with or witho