Low molecular weight heparin; a novel alternative therapeutic approach for lichen planus

✍ Scribed by M.P. Stefanidou; D.J. Ioannidou; J.G. Panayiotides; A.D. Tosca

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 420 KB
• Volume: 141
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.1999.03202.x

✦ Synopsis

Heparin analogues in low doses have antiproliferative and immunomodulatory properties. The aim of this study was to evaluate the effect of low-dose enoxaparin administered subcutaneously in lichen planus (LP). Eighteen patients with various types of LP were treated in an open study for 6-13 weeks. Efficacy and safety data were recorded. Complete remission was observed in 11 of 18 patients (61%) and marked improvement in two (11%). Widespread cutaneous involvement and reticulated oral LP had the best response, while in LP of the scalp the response was poor. Enoxaparin is a promising alternative therapy for various types of LP.