CI-940, PD 114,721, and PD 118,607 are structurally novel antibiotics, which were isolated from fermentation beers of a previously unknown actinomycete. They are highly lipophilic acids characterized by unsaturated lactone and branched, polyunsaturated aliphatic side-chain moieties. All three agents
Low molecular weight analogs of trolox with potent antioxidant activity in vitro and in vivo
β Scribed by Dr. Paul J. Silver; Robert J. Gordon; Patrick J. Horan; Cynthia R. Bushover; William P. Gorczyca; John R. Etzler; R. Allan Buchholz; Donald Schlegel; George J. Ellames; David I. Smith; Alan M. Ezrin
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 514 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0272-4391
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Copoly(o-lactic acid/L-lactic acid; o-LA/L-LA) with relatively low molecular weight (/14nll of 300-3800, was synthesized by direct copolycondensation without catalyst in an atmosphere of nitrogen at 200 C, to evaluate the difference in degradation between crystalline and amorphous copolymers. The no
## Abstract Two new families of closely related selective, nonβcytotoxic, and potent antitubercular agents were discovered: thioquinolines and thiazoloquinolines. The compounds were found to possess potent antitubercular properties inβ vitro, an activity that is dependent on experimental conditions
A disturbed embryonic antioxidant defense mechanism may play a major role in diabetesinduced teratogenesis. We therefore studied the antioxidant capacity of 10.5-day-old rat embryos and their yolk sacs after culture for 28 hr in vitro under diabetic conditions (3 mg/ml glucose, 2 mg/ml β€-hydroxybuty