Low-melting phenytoin prodrugs as alternative oral delivery modes for phenytoin: A model for other high-melting sparingly water-soluble drugs
✍ Scribed by Yumiko Yamaoka; Richard D. Roberts; Valentino J. Stella
- Book ID
- 102917242
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 671 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
greater than it would be from the same application placed on normal skin. Given the variable but potentially high, permeability through eschar and the violent systemic toxicity (14), phenol should not be used for burnwound antiseptics.
Another factor is that the chemical burn effected by the highest phenol concentration (6% w/v) in a preceding study (7) and the thermal burns effected here at temperatures >8O0 are of comparable permeability. This suggests that the chemical and thermal treatments cause the same type of destructive alteration of the stratum comeum, albeit by vastly different mechanisms, resulting in a functional impairment of the same order. We regard this as strong evidence that the stratum corneum proteins are involved and denatured by extreme treatments of either kind. It is hard to envision a means whereby these different treatments could produce like effects in purely lipid domains in the stratum corneum. By either procedure the stratum corneum loses some or all of the ability to differentiate permeating species on the basis of polarity, depending on the intensity of the burn.
REFERENCES
(1) T. D.