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Low levels of mycophenolic acid induce differentiation of human neuroblastoma cell lines

✍ Scribed by Elisa Messina; Paola Gazzaniga; Vanna Micheli; Lucio Barile; Federico Lupi; Anna Maria Aglianò; Alessandro Giacomello

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
120 KB
Volume
112
Category
Article
ISSN
0020-7136

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✦ Synopsis

In a previous report, 1 we showed that mycophenolic acid (MPA), at concentrations readily attainable during immunosuppressive therapy (0.1-10 M), using its mycophenolate mofetil prodrug, causes a decrease of intracellular levels of guanine nucleotides, G 1 arrest and time-and dose-dependent death by apoptosis. The first effect appears to be the consequence of inosine monophosphate dehydrogenase (IMPDH)

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